Data show that fragile X-associated tremor/ataxia syndrome with defective neuronal RNA transport can be connected
Main category: Neurology / neuroscience
Also included in: genetics
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SUNY Downstate scientist Ilham Muslimov, MD, PhD, along with senior author Henri Tiedge, PhD, professor of physiology and pharmacology and of neurology, published a study suggesting that cellular dysregulation associated with certain neurodegenerative disorders may result from molecular competition in neuronal RNA transport pathways.
The paper appeared in the journal titled of cell biology, "spatial code recognition in neuronal RNA targeting: role of RNA-hnRNP A2 interactions." The article which highlighted in to accompanying editorial, "RNA Targeting Gets Competitive."
Dr. Tiedge notes, "in contrast to DNA, in which information coding is one-dimensional (i.e. linear), RNA can encode information in three-dimensional architectural motifs." "Dr. Muslimov has now identified RNA motifs that act as spatial codes in directing RNA to dendrites and synapses nerve cells,." A synapse is a junction that allows a neuron (nerve cell) to pass on electrical or chemical signal to another cell, and biology are the branched processes of neurons that act to conduct electrochemical stimulation to the neuronal cell body.
He adds, "just like number 7 on a New York subway train is a code for the destination 'Times Square' Dr. Muslimov's RNA motifs are codes for the dendrite and synapse destinations." "They make sure RNAs are delivered to cellular sites where they are supposed to operate."
"Sometimes, on RNA may express to inappropriately high number of targeting motifs, with the result that the resources of the transport system become overwhelmed." It is as if too many passengers are trying to enter trains at the same time, exceeding system capacity. "We have congestion, and transport is disrupted."
Dr. Tiedge explains that Dr. Muslimov's work indicates that in nerve cells, excessive competition for common transport resources may result in compromised dendritic delivery of RNA. "In the example studied Dr. Muslimov, the culprit is an RNA that contains the genetic information for the fragile X mental retardation protein." "Once the number of motifs structures in this RNA exceeds a threshold (usually around 55), the RNA becomes excessively competitive and begins to commandeer, at the expense of other RNAs, common resources of the cellular transport system."
"Dr. Muslimov's data raise the possibility that the resulting neurodegenerative disease, the fragile X-associated tremor/ataxia syndrome, is precipitated by a neuronal transport problem," Dr. Tiedge concludes.
Article adapted by medical news today from original press release.Visit our neurology / neuroscience section for the latest news on this subject.
Please use one of the following formats to cite this article in your essay, paper or report:APA
SUNY Downstate Medical Center (2011, September 9). Data suggest that fragile X-associated tremor/ataxia syndrome may be linked to Dysregulated neuronal RNA transport. Medical news today. Retrieved September 9, 2011 from http://www.medicalnewstoday.com/releases/234095.php MLA
SUNY Downstate Medical Center. "Data suggest that fragile X-associated tremor/ataxia syndrome may be linked to Dysregulated neuronal RNA transport". Medical news today, September 9, 2011. Web. 9 Sep, 2011.
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