Category: Genetics
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Spontaneous order of DNA fragments in a special matrix is the key to gene vectors, create treatment non-toxic delivery that recently in European physical according to a study, journal E.

Scientists of the CNRS Paul Pascal Research Centre, an Institute of the University of Bordeaux in France, and colleagues from the Institute of physics created a complex system, the University of Sao Paolo, which for this designed to keep DNA fragments in solution between the hydrophilic layers of a matrix of fatty substances (also, lipids) along with certain of the surfactant (used to reduce the levels of stiffness). Gene therapy is a possible application so far still not tested.

Although gene therapy was initially delivered using viral vectors, the recent attempts to develop of alternative vectors have with positively charged lipids form complex structures with DNA fragments taken advantage of electrostatic forces. However the positively charged ions that have used known as cations, in this type of vector for human cells has proven reliable.

Until now only positively charged fatty substance were suitable DNA in a complex vector operation. The authors of this study have opposite demonstrated by creating an electrically neutral matrix, like a layered cake, the DNA fragments in a high concentration in the solution between the layers built up.

The authors found that organize DNA fragments within the complex in the course of time. These fragments to align spontaneously parallel to each other and form rectangular and hexagonal structures across the Plains. The emergence of ordered structures in high concentrations in DNA explains the change of atomic level interactions within the levels and the representation of interactions at the interface between the layers and of DNA molecules.

The next step of the research are the exact physical forces that hold together the plant research. Applications of go gene therapy vector design, how you can apply the same principle for the supply of other particles such as chemical drugs.

Sources: Springer Science + Business Media, AlphaGalileo Foundation.

Articles from medical news today adapted from original press release.

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Springer Science + Business Media (September 9, 2011). New complex offers potentially safer alternative for the delivery of gene therapy. Medical news today. Retrieved 9 September 2011 by http://www.medicalnewstoday.com/releases/234122.php MLA
Springer Science + business media. "New plant offers possibly safer alternative gene therapy delivery". Medical news today, September 9 2011. Web. 9 Sep, 2011.

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